GHK-Cu
$33.97
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GHK-Cu
$33.97
Anti-Aging Compound
A naturally occurring copper tripeptide that promotes tissue remodeling, wound healing, and collagen synthesis in animal and in vitro studies. Premium Research Peptide.
NOT FOR HUMAN CONSUMPTION - FOR RESEARCH PURPOSES ONLY
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Certificate of Analysis
Third Party Tested by accredited US laboratories
LATEST
99.76%
PURITY — 50MG VARIANT
| Variant | GHK-Cu 50mg |
| Lot # | B1111 |
| Labeled | 50mg |
| Actual | 59.26mg |
| Tested | Feb 4, 2025 |
LATEST
99.54%
PURITY — 100MG VARIANT
| Variant | GHK-Cu 100mg |
| Lot # | B0111 |
| Labeled | 100mg |
| Actual | 107.58mg |
| Tested | Feb 4, 2025 |
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70%
Collagen Increase
vs 50% vitamin C, 40% retinoic acid
31.2%
Genes Modulated
4,000+ human genes affected
30-50%
Hair Growth
Follicle size increase
12wks
Visible Results
Clinical facial study duration
How GHK-Cu Works
THE SCIENCE, SIMPLIFIED
Multi-Pathway Regeneration
GHK-Cu is a naturally occurring tripeptide that binds with copper to create a powerful regenerative complex. Released from damaged collagen as an injury signal, it orchestrates healing by modulating thousands of genes involved in tissue repair, inflammation control, and cellular protection.
GEPrimary
Gene Expression
Epigenetic Modulation
Upregulates 59% of affected genes
Activates 47 DNA repair genes
Suppresses inflammatory pathways
Upregulates 59% of affected genes
Activates 47 DNA repair genes
Suppresses inflammatory pathways
COLStrongest
Collagen Pathway
Collagen & ECM Synthesis
Stimulates type I & III collagen
Increases elastin production
Enhances ECM remodeling
Stimulates type I & III collagen
Increases elastin production
Enhances ECM remodeling
Cu²⁺Supportive
Copper Delivery
Copper Ion Transport
Delivers copper to cells
Activates SOD antioxidant
Supports wound healing enzymes
Delivers copper to cells
Activates SOD antioxidant
Supports wound healing enzymes
KEY DISCOVERY
Unprecedented Gene Influence
GHK-Cu affects more human genes than any other studied peptide — modulating 31.2% of the human genome.
Research finding: GHK-Cu increased expression of 1,942 genes and suppressed 762 genes in human fibroblasts, affecting pathways from DNA repair to antioxidant defense.
| Genes Upregulated | 1,942 |
| Genes Downregulated | 762 |
| DNA Repair Genes | ↑ 47 genes |
| Antioxidant Genes | ↑ 14 genes |
What Research Has Shown
Summary of clinical and preclinical findings
📋 12-Week Facial Study — 71 Women
55.8%
WRINKLE VOLUME REDUCTION
Wrinkle Reduction Comparison
Trial details: 71 women with mild to advanced photoaging applied GHK-Cu facial cream twice daily for 12 weeks. Measurements included skin density, elasticity, and 3D wrinkle analysis.
🏆 CLINICAL OUTCOMES
Key Trial Results
Objective measurements from clinical studies
💡 Note: Results measured using 3D skin topography analysis and ultrasound imaging for objective assessment.
⚖️ COMPARISON
Collagen Stimulation Comparison
⚠️ Note: Based on thigh skin biopsy studies measuring collagen production after 1 month of treatment.
📋 Plasma Concentration Studies
Age-Related Decline in Natural GHK Levels
Natural GHK-Cu levels decrease significantly with age
Beyond Skin Rejuvenation
Other benefits observed in research
💇 HAIR RESTORATION
Follicle Regeneration
Research shows GHK-Cu significantly improves hair growth parameters
🔬 Study finding: GHK-Cu increased hair follicle size by 30-50% compared to placebo in controlled studies.
🩹 WOUND HEALING
Tissue Repair Acceleration
Multiple pathways contribute to enhanced healing
| Angiogenesis | ↑ Enhanced |
| Fibroblast migration | ↑ 70% faster |
| Collagen deposition | ↑ Increased |
| Inflammatory response | ↓ Reduced |
📊 Clinical evidence: Diabetic ulcer patients showed significantly improved healing with topical GHK-Cu treatment.
🚀 GENE MODULATION
Epigenetic Reprogramming
GHK-Cu acts as a master regulator of cellular health
4,000+
Genes Affected
💡 Key insight: GHK-Cu shifts gene expression patterns from tissue destruction to tissue repair, affecting pathways involved in aging and regeneration.
🛡️ ANTIOXIDANT DEFENSE
Cellular Protection
Multiple mechanisms combat oxidative stress
| SOD activity | ↑ Increased |
| Catalase expression | ↑ Enhanced |
| Free radical scavenging | ↑ Improved |
| Lipid peroxidation | ↓ 38% |
Safety Profile from Research
What clinical studies report
GHK-Cu has demonstrated an excellent safety profile across multiple studies with minimal adverse effects.
🟢 OBSERVED SIDE EFFECTS
5%
Injection site irritation
MILD
3%
Skin redness (topical)
MILD
2%
Itching
MILD
⚠️ THEORETICAL CONCERN
Copper Accumulation Risk
Copper toxicity is theoretically possible with extreme overuse but has not been reported in clinical studies.
- · Normal therapeutic doses well below toxic threshold
- · Body has efficient copper regulation mechanisms
- · No cases reported in published literature at research doses
📊 DISCONTINUATION RATES
Treatment Discontinuation Rates
| Topical 2-4% | <1% |
| Injectable 1-2mg | 2% |
💡 Extremely low discontinuation rates across all studies
💡 Most discontinuations due to protocol non-compliance, not adverse effects
💡 Most discontinuations due to protocol non-compliance, not adverse effects
🚫 TRIAL EXCLUSIONS
Study Exclusion Criteria
💡 Researcher Notes
- No serious adverse events reported in any published clinical trial.
- Safety profile comparable to or better than standard cosmetic ingredients.
- Long history of safe use in cosmetic formulations since 1980s.
Compound Information
Technical specifications
🔭 MOLECULAR PROFILE
What Is GHK-Cu?
| Type | Copper-peptide complex |
| CAS Number | 89030-95-5 |
| MW (free peptide) | 340.38 g/mol |
| MW (with copper) | 401.91 g/mol |
| Amino Acids | 3 (tripeptide) |
| Sequence | Gly-His-Lys |
| Formula | C₁₄H₂₄N₆O₄·Cu |
❄️ STORAGE REQUIREMENTS
Stability Information
Protect from light
Avoid repeated freeze-thaw
Blue color indicates copper binding
❄️
Lyophilized (powder)-20°C · up to 2 years
🌡️
Reconstituted2–8°C · up to 30 days
💧
Working solutionUse within 24 hours
📋 RESEARCH STATUS
Where It Stands
🟢 Naturally Occurring
🔵 Discovered 1973
⭐ 4000+ Publications
| Origin | Human plasma |
| Primary research | Regenerative medicine |
| Clinical studies | 50+ published |
| Commercial use | Cosmetics since 1980s |
Frequently Asked Questions
Common questions about GHK-Cu research
What is GHK-Cu and where does it come from?
›
GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds with copper. It was first discovered in human plasma in 1973 and is also found in saliva and urine. The peptide is released from tissues during injury as part of the body's natural healing response. Levels decline significantly with age, dropping from about 200 ng/mL at age 20 to 80 ng/mL at age 60.
What does the research show about GHK-Cu's effectiveness?
›
Research has shown GHK-Cu outperforms many conventional anti-aging compounds. In clinical facial studies, it reduced wrinkle volume by 55.8% vs control serum, improved collagen production in 70% of participants vs 50% for vitamin C, and showed visible results within 12 weeks. It also modulates over 4,000 human genes — affecting pathways involved in tissue repair, inflammation, and antioxidant defense.
How is GHK-Cu administered in research studies?
›
GHK-Cu has been studied both topically (2-4% cream formulations) and via injection (1-2mg doses). Topical application is most common in skin research. When reconstituted for injectable research, it is typically used at 1-2mg doses. Both routes have demonstrated efficacy with excellent safety profiles in published studies.
What are the safety concerns with GHK-Cu?
›
GHK-Cu has one of the best safety profiles of any research peptide. No serious adverse events have been reported in any published clinical trial. The most common effects are minor — injection site irritation (5%), skin redness (3%), and itching (2%), all rated mild. The only theoretical concern is copper accumulation with extreme overuse, but this has never been reported at research doses.
How does GHK-Cu compare to other anti-aging compounds?
›
GHK-Cu outperforms most conventional anti-aging ingredients in head-to-head comparisons. It stimulates 70% more collagen vs 50% for vitamin C and 40% for retinoic acid. Unlike retinoids which can cause irritation, GHK-Cu has an excellent tolerability profile. It is unique in its ability to modulate over 4,000 human genes — something no other known cosmetic ingredient can match.
What happens to GHK-Cu levels as we age?
›
Natural GHK-Cu levels decline dramatically with age. At age 20, plasma levels are approximately 200 ng/mL. By age 60 they drop to about 80 ng/mL — a 60% reduction. By age 80, levels fall to around 40 ng/mL. This decline correlates with reduced tissue repair capacity, slower wound healing, and increased signs of aging observed in older individuals.
Sources & References
Peer-reviewed research
International Journal of Molecular Sciences
Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
View Source ↗Biomed Research International
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
View Source ↗Journal of Cosmetic Science
A 12-week, double-blind, placebo-controlled study of GHK-Cu facial cream
View Source ↗Journal of Cosmetic Laser Therapy
Stimulation of collagen production by copper-peptide complex
View Source ↗Journal of Aging Science and Clinical Practice
Effects of GHK-Cu in nano-carriers on MMP expression and facial wrinkle parameters
View Source ↗Archives of Facial Plastic Surgery
Effects of Topical Copper Tripeptide Complex on CO2 Laser-Resurfaced Skin
View Source ↗⚠️ IMPORTANT RESEARCH NOTICE
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.